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Why some “breakthrough” technologies don’t work out

Why some “breakthrough” technologies don’t work out

Every year, MIT Technology Review publishes a list of 10 Breakthrough Technologies. In fact, the 2026 version is out today. This marks the 25th year the newsroom has compiled this annual list, which means its journalists and editors have now identified 250 technologies as breakthroughs.  A few...

Mechanistic interpretability: 10 Breakthrough Technologies 2026

Mechanistic interpretability: 10 Breakthrough Technologies 2026

Hundreds of millions of people now use chatbots every day. And yet the large language models that drive them are so complicated that nobody really understands what they are, how they work, or exactly what they can and can’t do—not even the people who build them. Weird, right? It’s also a problem....

Meet the new biologists treating LLMs like aliens

Meet the new biologists treating LLMs like aliens

How large is a large language model? Think about it this way. In the center of San Francisco there’s a hill called Twin Peaks from which you can view nearly the entire city. Picture all of it—every block and intersection, every neighborhood and park, as far as you can see—covered in sheets of...

Good technology should change the world

Good technology should change the world

The billionaire investor Peter Thiel (or maybe his ghostwriter) once said, “We were promised flying cars, instead we got 140 characters.” That quip originally appeared in a manifesto for Thiel’s venture fund in 2011. All good investment firms have a manifesto, right? This one argued for making bold...

The Download: the case for AI slop, and helping CRISPR fulfill its promise

The Download: the case for AI slop, and helping CRISPR fulfill its promise

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. How I learned to stop worrying and love AI slop —Caiwei Chen If I were to locate the moment AI slop broke through into popular consciousness, I’d...

A new CRISPR startup is betting regulators will ease up on gene-editing

Here at MIT Technology Review we’ve been writing about the gene-editing technology CRISPR since 2013, calling it the biggest biotech breakthrough of the century. Yet so far, there’s been only one gene-editing drug approved. It’s been used commercially on only about 40 patients, all with sickle-cell...